Thioredoxin has also been shown to bind to ASK1 to inhibit its activity as a kinase [32]. This inhibition is attenuated by ROS that can cause dimerization of thioredoxin [33]. Thioredoxin regulation in the glucocorticoid receptor by way of Affiliation with the DNA binding area has also been documented [34] which also is motivated by ROS. Much more

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